Q: What is transdermal absorption and Papua Agent?
A: The transdermal absorption preparation is to make the drug absorbed by the skin of human body enter into the blood circulation to play curative effect, so the transdermal absorption preparation is also called as transdermal therapy. The skin is the first line of defense for human body, with about 3mm thickness on average, covering about 2 square meters of the body, which is the largest tissue of human body. The skin is made of epidermis, dermis and subcutaneous tissue, containing rich capillary nets, and one-third of the whole body blood circulation is in the skin, which is helpful for the rapid absorption of the drug.
Generally, transdermal absorption preparation has several layers of structures such as the surface film, medicine-containing matrix, controlled-release film and protective film; it is also divided into the paster and Papua agent according to different matrix; the paster commonly uses pressure sensitive matrix, and Papua agent uses the water-soluble polymeric materials as medicine carrying matrix.
Q: What are the benefits of Papua agent?
A: (1) apply with comfort, breathe freely, without pain when removed, no residue on the skin, not sticky when contact with sweat; (2) with large amount of medicine carrying; (3) without "three wastes" in the production (completely avoid using organic solvent); (4) the applicable range is wide: it can be used for water soluble or fat soluble medicines, Chinese traditional medicine (powder) and its extract, etc; (5) the matrix contains the moisturizing composition such as water, glycerin and sorbitol, with the effects of moistening skin, promoting skin hydration (helpful for transdermal absorption of active ingredients); (6) it may be repeatedly sticked or removed, with small influence on viscosity; (7) without irritation and allergy to skin; (8) proper size may be cut when use according to the size of applied parts, to facilitate the adjustment of the dosage; (9) the effect is lasting.
Q: Can Teiyaku Yitieliang Cooling Sheet protect the brain?
A: Fever is the common symptom in life, the temperature too high or too long time can lead to the damage of nervous cells. Children growth is not perfect, so the fever can easily cause brain function disorder and unconsciousness, the whole body twitching and other symptoms, called as high fever convulsions; unless timely treatment, it can cause brain cell damage and affect intelligence development of children; or even cause epilepsy to produce learning and behavioral problems. So, the correct and proper cooling measures must be taken for fever.
The World Health Organization (WHO) points out: physical cooling measures should first be taken for fever. "Teiyaku Yitieliang Cooling Sheet" is the new physical cooling product, refined from polymer gel with mint and other natural ingredients; through the evaporation of gel moisture, the heat of human body is taken away, with the efficacy of cooling, relieving pain and tranquilizing the mind through the unique ingredients of transdermal absorption. In addition, this product has already been validated by the State Food and Drug Administration Medical Equipment Quality Supervision and Inspection Center, without skin sensitization or intracutaneous reactivity.
This product has effectively avoided the disadvantages of traditional physical cooling therapy, without stimulation to the skin, without pain when removed, easy to use and carry, which is the necessary article of family medicines.
Q: Can Teiyaku Cooling Gel Sheet replace antipyretic?
A: Application of "cooling gel sheet" is the auxiliary treatment method for fever, which can reduce the symptoms to avoid and reduce the harm of fever to human body, but to find out the root causes of the fever, it needs to go to a doctor for diagnosis and symptomatic treatment.
It is suggested that the first step for defervescence is to use "cooling gel sheet" for physical cooling, to ease the illness and protect the brain from damage, and then go for medical treatment in a timely manner, to eliminate the pathogenic root.
In and after the process of medical treatment, it still needs to cooperatively use "cooling gel sheet" for emergency care, in order to protect the brain cells from damage, to accelerate cooling and promote rehabilitation.
Q: Can Teiyaku Yitieliang Cooling Sheet lower the temperature?
A: 1. Teiyaku Yitieliang Cooling Sheet is a physical cooling paster, which can produce the local cooling effect--the local cooling of brain to protect the brain.
2. Usually, we use the armpit temperature to show the body temperature, and armpit temperature represents the whole body temperature; clinically, brain temperature is represented by nose and pharynx temperature, but it is difficult to measure.
3. Yitieliang Cooling Sheet can have the whole body cooling effect, which is closely related to the age, body surface area and fever degree. Experiment shows that the infant using Yitieliang Cooling Sheet for an hour, the armpit temperature can reduce 1℃ or so.
4. It can be applied in several places, such as forehead, neck, armpit and groin to increase the evaporation area and the cooling effect is better.  

Q: What’s the difference between Yitieliang Cooling Sheet and traditional cooling methods?
A:

Q: Why could hydrogel show so powerful water absorbability?
A:Adding PAAS is help to improve hydro gel’s hydrophilism and adhesiveness. PAAS is a kind of SAP, and the remarkable feature of SAP is powerful water absorbability. PAAS could absorb water 100-1000 times or normal saline 20-60 times as much as its own weight and hold water after swelling.
The high water absorbability of PAAS mainly depends on the balance of below 3 forces:
1、Osmotic Pressure ---- Absorbability
The osmotic pressure of ions dissociated in the hydrogel is the key factor to its water absorbability. The higher osmotic pressure generates the stronger water absorbability.
2、Hydrophilicity---- Osmotic Force
The higher hydrophilicity generates the greater water absorbability. SAP with hydrophilic carboxyl could absorb water rapidly. The smaller Particle has larger surface area, so that it could absorb water more rapidly.
3、Crosslinking Density---- Retention Capacity
SAP could be light crosslinked into meshwork structure, and keep swelling as a balloon after absorbed water. The lower crosslinking density causes the bigger meshwork and the greater water absorbability.